ABSTRACT
Interferon regulatory factor -4 binding protein ( IBP ) , served as a novel type of microtubule binding protein ,is proven to play an important role in the immune system .New evidence suggests that the protein is associated with the occurrence and development of some malignant tumors through the effects of cytoskeletal re -modeling and cell conduction mechanism .Therefore researchers believe that IBP may become a new target for cancer molecular therapy .Based on the existing experimental data ,this study aims to investigate the structure of IBP,as well as its multiple oncology effects .Furthermore,we provide the theoretical basis for IBP targeted therapy in the treatment of malignant tumors .
ABSTRACT
Epithelial ovarian cancer( EOC) is the most deadly malignant tumor in gynecological cancer. In the past 30 years,although the levels of diagnosis and treatment have made progress,the incidence of EOC and mortality are constant. Over the past few decades,a comprehensive study for molecular mechanisms of EOC pro-gression has been conducted in order to develop new and more effective treatments. Advanced peritoneal metasta-ses occur in the attached small clusters of cancer cells,which shed from the initial site and carried it through the ascites to the abdominal peritoneum or omentum. This behavior suggests that cell-cell or cell-matrix adhesion mechanisms regulate the growth and dissemination of EOC. Complex downstream signaling may be affected by functional crosstalk between adhesion molecules and,co-expressed and activated signaling proteins,which affect the proliferation/survival and migration/invasion of EOC cells. The aim of this review is to define effects of cell and cellular mechanisms,which are adhered by the cadherin and the cell-extracellular matrix,and cascaded by integrin-mediated membrane receptor and cytoplasmic protein -mediated cascade amplification, which is ex-pressed in proliferation,migration and invasion of epithelial ovarian cancer cells.